Ferrari continued with its development of two absolute jewels at this particular time: the two V12s designed respectively by Gioachino Colombo and Aurelio Lampredi. Columbo’s touch was still very much in evidence in the 225 S’s engine, although the improvements made to it were entirely the result of Lampredi’s research, particularly the strikingly innovative and efficient design of the intake manifold and the distribution. A number of examples were built using Gilco’s “Tuboscocca” (tubular semi-monocoque) chassis design, while the bodywork bore witness to the artistry of Touring and Vignale, both at the height of their creativity at that time.

Accurate selection of the best shots of the 225 S in high definition. The photo gallery shows the distinctive features of this model Ferrari in 1952, focusing on the details and the most important parts.
| Type | front, longitudinal 60° V12 |
| Bore/stroke | 70 x 58.8 mm |
| Unitary displacement | 226.28 cc |
| Total displacement | 2715.46 cc |
| Compression ratio | 8.5 : 1 |
| Maximum power | 154 kW (210 hp) at 7200 rpm |
| Power per litre | 77 hp/l |
| Maximum torque | - |
| Valve actuation | single overhead camshaft per bank, two valves per cylinder |
| Fuel feed | three Weber 36 DCF carburettors |
| Ignition | single spark plug per cylinder, two coils |
| Lubrication | wet sump |
| Clutch | single-plate |
| Frame | tubular steel |
| Front suspension | independent, unequal-length wishbones, transverse leaf spring, hydraulic shock absorbers |
| Rear suspension | live axle, twin semi-elliptic springs, hydraulic shock absorbers |
| Brakes | drums |
| Transmission | 5-speed + reverse |
| Steering | worm and sector |
| Fuel tank | - |
| Front tyres | 5.50 x 16 |
| Rear tyres | 6.00 x 16 |
| Type | two-seater berlinetta, spider |
| Length | - |
| Width | - |
| Height | - |
| Wheelbase | 2250 mm |
| Front track | 1278 mm |
| Rear track | 1250 mm |
| Weight | 850 kg (dry) |
| Top speed | 230 km/h |
| Acceleration 0-100 km/h | - |
| 0-400 m | - |
| 0-1000 m | - |