The 375 Mille Miglia carried on the Ferrari tradition of naming sports models after the famous Italian road race and was a spin-off of the F1 single-seater, just like its sister car, the 375 America, which was the GT equivalent.
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The engine was based on its F1 counterpart, albeit with a new crankshaft giving a shorter, 68 mm stroke but with a bigger bore for a larger, 4.5-litre displacement. The engine debuted in a 340 berlinetta at Le Mans where it was driven by Ascari and Villoresi. Subsequently Pinin Farina built a series of around 10 spiders and a few berlinettas which were mainly fielded by privateers.
| Type | front, longitudinal 60° V12 |
| Bore/stroke | 84 x 68 mm |
| Unitary displacement | 376.84 cc |
| Total displacement | 4522.68 cc |
| Compression ratio | 9 : 1 |
| Maximum power | 250 kW (340 hp) at 7000 rpm |
| Power per litre | 75 hp/l |
| Maximum torque | - |
| Valve actuation | single overhead camshaft per bank, two valves per cylinder |
| Fuel feed | three Weber 40 IF/4C or 42 DCZ carburettors |
| Ignition | single spark plug per cylinder, two magnetos |
| Lubrication | wet sump |
| Clutch | multi-plate |
| Frame | tubular steel |
| Front suspension | independent, unequal-length wishbones, transverse leaf spring, anti-roll bar, Houdaille hydraulic shock absorbers |
| Rear suspension | live axle, semi-elliptic springs, twin radius arms, twin Houdaille hydraulic shock absorbers |
| Brakes | drums |
| Transmission | 4-speed + reverse |
| Steering | worm and sector |
| Fuel tank | capacity 180 litres |
| Front tyres | 6.50 x 16 |
| Rear tyres | 6.50 x 16 |
| Type | two-seater berlinetta, spider |
| Length | - |
| Width | - |
| Height | - |
| Wheelbase | 2600 mm |
| Front track | 1325 mm |
| Rear track | 1320 mm |
| Weight | 900 kg (dry) |
| Top speed | 289 km/h |
| Acceleration 0-100 km/h | - |
| 0-400 m | - |
| 0-1000 m | - |