Just like the two-litre version, the Dino 246 S shared a similar styling to the 250 Testa Rossa of the same era, but was equipped with an engine derived from Formula 1. This version debuted in January 1960 at the Buenos Aires 100 km during the Temporada Argentina in the hands of Scarfiotti and Gonzalez. Two cars also took part in the Targa Florio, coming home second and fourth respectively. Although the Dino 246 S was subsequently used extensively by privateers, the official Ferrari works drivers only fielded the 250 Testa Rossa.

| Type | front, longitudinal 60° V6 |
| Bore/stroke | 85 x 71 mm |
| Unitary displacement | 402.88 cc |
| Total displacement | 2417.33 cc |
| Compression ratio | 9.8 : 1 |
| Maximum power | 184 kW (250 hp) at 7500 rpm |
| Power per litre | 103 hp/l |
| Maximum torque | - |
| Valve actuation | single overhead camshaft per bank, two valves per cylinder |
| Fuel feed | three Weber 42 DCN carburettors |
| Ignition | single spark plug per cylinder, single coil |
| Lubrication | wet sump |
| Clutch | multi-plate |
| Frame | tubular steel |
| Front suspension | independent, unequal-length wishbones, coil springs, telescopic shock absorbers, anti-roll bar |
| Rear suspension | live axle, radius arms, coil springs, telescopic shock absorbers |
| Brakes | discs |
| Transmission | 5-speed + reverse |
| Steering | rack-and-pinion |
| Fuel tank | capacity 120 litres |
| Front tyres | 5.50 x 15 |
| Rear tyres | 6.00 x 15 |
| Type | two-seater spider |
| Length | - |
| Width | - |
| Height | - |
| Wheelbase | 2160 mm |
| Front track | 1245 mm |
| Rear track | 1205 mm |
| Weight | 640 kg (dry) |
| Top speed | - |
| Acceleration 0-100 km/h | - |
| 0-400 m | - |
| 0-1000 m | - |